순천향의생명연구원(SIMS)

PROFESSIONAL SUMMARY

• My research is focused on “Cancer Precision Therapy” which promises personalized cancer treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each patient.

• Broad spectrum of expertise in cancer biology and analysis of patient database

RESEARCH INTERESTS

• Elucidating mechanisms of DNA repair following DNA damage stresses

• Finding candidate drugs for combination cancer therapy

• Analyzing genomic DNA of patients & designing of precision medicine

Essentials of Cancer Genomic, Computational Approaches and Precision Medicine. (2020)

Principle investigator

Wootae Kim

Assistant Professor. Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea

Assistant Professor, Dept. of Pharmacology, Mayo Clinic, USA

Research Fellow, Division of Oncology Research, Mayo Clinic, USA

Postdoctoral Fellow, Dept. of Biomedical Science, Kyung Hee University, Korea

Ph.D. in Biomedical Science, Kyung Hee University, Korea

M.S. in Biomedical Science, Kyung Hee University, Korea

B.S. in Biomedical Science, Inje University, Korea

[Corresponding Author’s Article]

1. Chen L, Hou J, Guo Q, Zeng X, Deng M, Zhao F, Wu M, Tu X, Kloeber J, Huang J, Luo K, Yin P, Kim W*, Lou Z*. LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair. Clinical and Translational Medicine. 2021 (IF 11.492)

[First Author’s Articles]

12. Zhao F*, Kim W*, Lou Z. Yuan J. ASTE1 Orchestrates Shieldin Complex Mediated DNA Repair by Attenuating End Resection. Nature Cell Biology. 2021 (IF 28.824)

11. Kim W*, Zhao F*, Gao H, Qin S, Deng M, Kloeber J, Huang J, Zhou Q, Guo G, Gao M, Tu X, Zeng X, Zhu S, Wu Z, Yin P, Kaufmann S, Luo K, Lou Z. USP13 regulates the replication stress response by deubiquitinating TopBP1. DNA repair. (Amst). 2021 (IF 4.913)

10. Zhao F*, Kim W*, Kloeber JA, Lou Z. DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells. Experimental and Molecular Medicine. 2020 (IF 8.718)

9. Kim W, Zhao F, Wu R, Nowsheen S, Huang J, Zhou Q, Qin S, Chen Y, Deng M, Guo G, Luo K, Yuan J, Lou Z. Zinc finger protein 161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex. Nature Communications. 2019 (IF 14.919)

8. Kim W, Ryu J, Kim JE. CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells. International Journal of Molecular Sciences. 2019 (IF 5.923)

7. Kim W, Pyo J, Byeong-Joo Noh, Joo-Won Jeong, Juhie Lee, Kim JE. CCAR2 negatively regulates IL-8 production in cervical cancer cells. Oncotarget. 2017

6. Kim W, Cheon MG, Kim JE. Mitochondrial CCAR2/DBC1 and its binding partner Hsp60 protect neuroblastoma cells from mitochondrial stress. Biochemical and Biophysical Research Communications. 2017 (IF 3.575)

5. Kim W, Jeong JW, Kim JE. CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells. Tumor Biology. 2014

4. Kim W, Choi MJ, Kim JE. The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle. Cell Cycle. 2014 (IF 4.534)

3. Kim W, Kim JE. Sirtuin 7 is an emerging sirtuin: Deciphering newer roles. Journal of Physiology and Pharmacology. 2013 (IF 3.011)

2. Kim W, Kim JE. Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage. Cancer Letters. 2013 (IF 8.679)

1. Kim W, Park G, Kim R, Park JW, Kim JE. The deficiency of H3K79 histone methyltransferase DOT1L inhibits cell proliferation. Journal of Biological Chemistry. 2012 (IF 5.157)