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Faculty

  • Kae Won Cho, Ph.D.

    Associate Professor

    Obesity, Type 2 Diabetes, Immunometabolism, Adipose Tissue, Macrophages

    Room 408, SIMS

    +82-41-413-5028

    kwcho@sch.ac.kr

Cho Laboratory has a long-term research interest in understanding the mechanism and regulation of chronic inflammation in obese adipose tissue which contribute to the development of metabolic disease.

 

Obesity, Type 2 Diabetes, and Immunometabolism

Obesity has become a major risk factor for other metabolic diseases such as type 2 diabetes, atherosclerosis, and other cardiovascular diseases, even death. Obesity prevalence is increasing worldwide, which also influences adolescent. Adipose tissue plays a big role in the development of obesity as a site of chronic inflammation. Adipose tissue is an important endocrine organ, that produces adipokines as a systemic regulator of metabolism, moreover also has immunoregulatory properties as a site of activated-leukocytes accumulation. Interference of adipose tissue leukocytes homeostasis could alter obesity-associated inflammation. Our lab has an interest in understanding how overnutrition could lead to adipose tissue inflammation, where homeostasis of adipose tissue immune cells disrupted, which then leads to local insulin resistance and contribute to peripheral insulin resistance that eventually leads to metabolic syndrome.

 

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Epigenetic mechanisms linking chronic inflammation to metabolic disease development

Epigenetics is defined as heritable changes to gene expression independent of changes to the DNA sequence. The epigenome includes DNA methylation, histone modifications, and RNA-mediated process, and disruption of this balance cause several ppathologies and contribute to obesity and type 2 diabetes. Our research goal is to gain more accurate understanding of how epigenetic and transcriptional regulators control (patho)physiology of adipose and other metabolic tissues. Ultimately, we hope to identify novel drug targets for more safe and efficient therapeutic intervention to relevant metabolic disorders including obesity and type 2 diabetes.


Principal Investigator



Kae Won Cho

Biography

B.S. in Animal Science, Korea University, Korea

M.S. in Biotechnology, Korea University, Korea

Ph.D. in Nutritional Program, Purdue University, USA

Postdoctoral Fellow, University of Michigan Medical School, USA

Staff Scientist, University of Michigan Medical School, USA

Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea

Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea 

 

Research Interest

- Adipose tissue inflammation and the development of metabolic disease

- Molecular mechanisms for adipose tissue macrophage polarization, recruitment and proliferation during obesity

- Epigenetic mechanisms linking chronic inflammation to metabolic disease development

- Identification and characterization of novel regulatory molecules in insulin sensitivity




Graduate Students


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