Faculty
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Song, Sujung, Ph.D.Professor
Cancer metabolism, Bone metastasis, Signaling pathway, Cancer stem cell, Genetic engineered mouse model (GEMM)
Room 406, SIMS
+82-41-413-5030
ssong1@sch.ac.kr
Cancer Metabolism and Metastasis Signaling
Our overarching goal is to identify the fundamental mechanisms responsible for molecular pathogenesis of human cancers and develop new and effective strategies for treatment and prevention of malignant diseases.
In pursuit of this goal, our laboratory embraces a multidisciplinary approach to improve our understanding of cancer signaling, cancer metabolism, and tumor immunology, particularly focusing on (1) the tumor-intrinsic and microenvironment signaling pathways underlying metabolism reprogramming in prostate and breast cancers (Cancer Cell 2017), and (2) the novel molecular drivers and regulatory networks of tumor initiation, growth and metastases (Nat Communication 2019), (3) the interplay between non-coding RNAs and epigenetic factors of cancer stem cells.
Our laboratory is focused on deciphering the functional landscape of (epi)genomes, (epi)transcriptomes, (phospho, ubiquityl)proteomes, and metabolomes in human cancers through state-of-the-art technologies, including ATAC-seq, MeRIP-seq/m6A-seq, IMAC proteomics, ubiquitomics, and metabolomices, and implementing preclinical studies of therapeutic targeting of novel oncogenes/tumor suppressors identified in our innovative mouse cancer models.
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Principal Investigator Sujung Song 2008. Ph.D. KAIST 2009. Postdoctoral Training. KAIST 2014. Postdoctoral Training. BIDMC, Harvard Medical School Present. Professor. SIMS, SCH University Ph.D Candidate Rebecca Stephanie Setijono E-mail: rebeccasteph06@sch.ac.kr Research Topic: Identifying a new regulator in cancer initiation and developement Hyesu Moon E-mail: hyesumoon0203@sch.ac.kr Research Topic: Understanding the role of metabolic reprograming in cancer cells Audrey Christine E-mail: 20207192@sch.ac.kr Research Topic: Exploring a new regulatory mechanism of cancer stem cells Alumni Zainab Syeda Ali Goeun Kim Siu Sema Langden |
1. IK Vila, MK Park, SR Setijono, Y Yao, H Kim, PM Badin, S Choi, V Narkar, SW Choi, J Chung, C Moro, MS Song*, SJ Song*. A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity. JCI Insight. 2019 Jul;4(13). DOI: 10.1172/jci.insight.128269
3. SR Setijono, MK Park, G Kim, Y Kim, KW Cho, SJ Song. miR-218 and miR-129 Regulate Breast Cancer Progression by Targeting Lamins. Biochem Biophys Res Commun. 2018 Feb;496(3):826–833. DOI: 10.1016/j.bbrc.2018.01.146
4. IK Vila, Y Yao, G Kim, W Xia, H Kim, SJ Kim, MK Park, JP Hwang, E González-Billalabeitia, MC Hung, MS Song*, SJ Song*. A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017 Feb;31(2):208–224. DOI: 10.1016/j.ccell.2017.01.003 (Cover Story of February issue on Cancer Cell)
5. SJ Song, L Poliseno, MS Song, U Ala, K Webster, C Ng, G Beringer, NJ Brikbak, X Yuan, LC Cantley, AL Richardson, PP Pandolfi. MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling. Cell. 2013 Jul;154(2):311–324. DOI: 10.1016/j.cell.2013.06.026
6. SJ Song*, K Ito*, U Ala, L Kats, K Webster, SM Sun, M Jongen-Lavrencic, K Manova-Todorova, J Teruya-Feldstein, DE Avigan, R Delwel, PP Pandolfi. The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation. Cell Stem Cell. 2013 Jul;13(1):87–101. DOI: 10.1016/j.stem.2013.06.003(Cover Story of February issue on Cell Stem Cell)
