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Faculty

  • Hyog Young Kwon, Ph.D.

    Associate Professor, Head of Department

    Hematopoietic stem cells (HSCs), Cancer Stem Cells (CSCs), Self-renewal, Regeneration, Fibrosis

    Room 308, SIMS

    +82-41-413-5021

    hykwon@sch.ac.kr

My lab is focused on cancer and cancer-associated diseases. Currently, we have four projects, including cancer stem cell, liver fibrosis and cancer, muscle wasting, and therapeutics.


Project I is identifying key signaling pathways in cancer stem cells (CSCs). CSCs have the ability to propagate cells, and are considered to be the cause of cancer relapse and metastasis. One of the key characteristics of both stem cells and cancer stem cells is their ability to self-renew. Due to the shared characteristics, it has been proposed that signals that regulate self-renewal of stem cells may also regulate the uncontrolled propagation of cancer cells. Thus, we have been interested in elucidating novel signaling pathways that regulate self-renewal of stem cells and how these same pathways are dysregulated in cancer formation.


Project II is studying liver fibrosis and liver cancer. Liver fibrosis is caused by liver damages, such as alcohol and virus infection, etc. and could be progressed into liver cancer. We are identifying key mechanistic insights on this progression using hepatic stellate cells and patient-derived samples.


Projct III is focused on muscle wasting or muscle atrophy. Muscle atrophy, such as sarcopenia and cachexia, that results in a state of weakness and atrophy of body is associated with many conditions, including aging, cancer, diabetes, and metabolic syndrome. We are elucidating the mechanisms and key signaling pathways implicated in muscle wasting.


Projct IV aims to develop therapeutic approaches against on the diseases mentioned above. We are studying immunotherapies using NKT or antibody against cancer, and testing small molecules against muscle wasting that we identified recently.






Principal Investigator


권혁영 (Hyog Young Kwon)

B.S. in pharmacy, Sung Kyun Kwan University, Korea

M.S. in pharmacy, Sung Kyun Kwan University, Korea

Ph.D. in pharmacy, Sung Kyun Kwan University, Korea

Postdoctoral fellow, Duke University, USA

Postdoctoral fellow, University of California, USA

Assistant Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea

Associate Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea 




Research Associate


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김광석 (Kwang Seock Kim)

Research associate since 2017

Studying on liver diseases, such as liver fibrosis and livercancer




Graduate Students


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Ita Novita Sari

Graduate student since 2015

Studying on cancer stem cells and hematopoietic stem cells


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Yoseph Toni Wijaya

Graduate student since 2018

Studying on muscle wasting and therapeutics


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Tania Setiawan

Graduate student since 2019

Studying on immunotherapy and leukemia


1. Wijaya YT, Setiawan T, Sari IN, Park K, Lee CH, Cho KW, Lee YK, Lim J, Yoon JK, Lee SH, Kwon HY. Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway. J Cachexia Sarcopenia and Muscle. 2022. 

 

2. Sari IN, Yang YG, Wijaya YT, Jun N, Lee S, Kim KS, Bajaj J, Oehler VG, Kim SH, Choi SY, Park SH, Kim DW, Reya T, Han J, Kwon HY. AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth. Oncogene. 2021;40(3):603-617. doi: 10.1038/s41388-020-01547-x. 

 

3. Sari IN, Setiawan T, Kim KS, Wiyaya YT, Cho KW, Kwon HY. Metabolism and function of polyamines in cancer progression. Cancer Lett. 2021 Jun 27;519:91-104. doi: 10.1016/j.canlet.

 

4. Yang Y, Koh YW, Sari IN, Jun N, Lee S, Phi LTH, Kim KS, Wijaya YT, Lee SH, Baek MJ, Jeong D, Kwon HY, Interferon-induced transmembrane protein 1-mediated EGFR/SOX2 signaling axis is essential for progression of non-small cell lung cancer. Int J Cancer. 2019 Apr 15;144(8):2020-2032. doi: 10.1002/ijc.31926. 

 

5. Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Tetraspanin3 is required for the development and propagation of Acute myelogenous leukemia. Cell Stem Cell, 2  2015 Aug 6;17(2):152-64. doi: 10.1016/j.stem.2015.06.006. 

 

6. Ito, T., Kwon HY, Zimdahl, B., Congdon, K. L., Blum, J., Lento, W. E., Zhao, C., Lagoo, A., Gerrard, G., Foroni, L., Goldman, J., Goh, H., Kim, S. H., Kim, D. W., Chuah, C., Oehler, V. G., Radich, J. P., Jordan, C.T., and Reya T.  Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature, 2010, 466, 765-8.