• Yoon, Jeong Kyo, Ph.D

    Professor, President of SIMS

    Stem cell biology, Signaling pathways, Tissue regeneration, Skeletal muscle, Lung

    Room 206, SIMS


Yoon laboratory has a long-term research interest in understanding the molecular mechanisms by which tissue homeostasis and regeneration are regulated. We are currently studying two specific tissues, skeletal muscle and lung, by utilizing both in vitro cell culture and in vivo mouse models.


Skeletal Muscle


Skeletal muscle tissue primarily functions for body locomotion and energy metabolism and is a highly dynamic tissue that responds to various physiological changes such as physical damage, exercise, nutrition, aging, and disease conditions. During the regeneration process after muscle injury or exercise, muscle stem cells (also called satellite cells) residing within the skeletal muscle generate nascent myofibers for repairing the damaged muscle or building additional muscle mass. Independent from the stem cell activity, regulation of myofiber mass is another key cellular process for skeletal muscle homeostasis. A balance between catabolic and anabolic metabolism of cellular proteins and subcellular organelles is critical. We are investigating (1) the molecular mechanisms underlying stem cell quiescence, proliferation, and myogenic commitment, and (2) the novel signaling pathways that control skeletal muscle mass.



Lung tissue has a vital function in gas exchange between the blood and the external atmosphere. It also has a critical role in the immune defense against external pathogens and environmental factors. While the lung is classified as a relatively quiescent organ with little homeostatic turnover, it shows robust regenerative capacity in response to injury, mediated by the resident stem/progenitor cells. During regeneration, regionally distinct epithelial cell populations with specific functions are generated from several different types of stem/progenitor cells localized within four histologically distinguished regions: trachea, bronchi, bronchioles, and alveoli. WNT signaling is critical to its developmental role in the embryonic and fetal lung. We currently explore how WNT signaling regulates different types of stem/progenitor cells in the lung for regeneration.

Principal Investigator


B.S. in Zoology, Seoul National University, Korea

M.S. in Zoology, Seoul National University, Korea

Ph.D. in Mammalian Genetics, University of Illinois at Chicago, USA

Research Fellow/ Senior Research Fellow, California Insititue of Technology, USA

Faculty Scientist I/II, Maine Medical Center Research Institute, USA

Associate Professor, Tufts University School of Medicine, USA

Professor, Soonchunhyang Institute of Medi-bio Science(SIMS), Soonchunhyang University, Korea


Research Interest

- Signaling pathways in skeletal muscle regeneration and stem cells

- Crosstalk between stem cells and other resident cells in skeletal muscle

- Positive and negative regulators of skeletal muscle mass and their acting mechanisms

- Regulation of stem cell function in lung regeneration

Research Associates


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Hyoshin Lee

Bachelor of Science in Life Science and Biomedical Science, Hallym University, Republic of Korea

Master of Science, Department of Integrated Biomedical Science, Soonchunhyang University. Republic of Korea

Graduate Students


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Jennifer Fransisca

Bachelor of Science, Atma Jaya Catholic University, Indonesia

Her research interest is to investigate about skeletal muscle niche components, particularly a group of mesenchymal progenitor cells called Fibro Adipogenic Progenitors (FAPs) that exhibit major impact in supporting muscle regeneration while become the main source of adipocyte and fibroblast infiltration in pathological muscle conditions.


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Bagus Sarmito

Bachelor of Science, Atma Jaya Catholic University, Indonesia

He is primarily interested in understanding the molecular mechanism by which skeletal muscle mass is regulated. Currently, he is studying a previously unknown role of chemokine CXCL14 in the regulation of skeletal muscle mass.


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Youn Jeong Oh

Bachelor of Science in Life Science, Hoseo University, Republic of Korea

Master of Science in Biochemistry, Hoseo University, Republic of Korea


Trinh Thi Tuyet Tran

PhD Candidate, Nanyang Technological University, Singapore

Nguyen Thi Thu Hao

Postdoctoral Fellow, University of Texas Health Science Center at Houston, USA

Hyunji Tak

Research Associate, DT  & CRO, Rebuplic of Korea

Yeeun Kim

Research Associate, DT  & CRO, Rebuplic of Korea

Ahmed Raslan

Assistant Professor, Department of Zoology, Assiut  University, Egypt

Jay Prakash Shah

Postdoctoral Fellow, University of Alabama at Birmingham, USA

1. Raslan A.A., Oh Y.J., Jin Y.R. and Yoon J.K.(2022). R-Spondin2, a positive canonical WNT signaling regulator,

2Dasgupta K., Cesario  J.M.,  Ha S.,  Asam K.,  Deacon L.J.,  Song A.H.,  Kim J.,  Cobb J.,  Yoon J.K. and  Jeong J. (2021) 

R-spondin 3 regulates mammalian dental and craniofacial development. J Dev Biol 9(3):31

3. Raslan,A.A., Yoon, J.K. (2020) WNT signaling in lung repair and regeneration. Molecules and Cells, 43: 774-783 (Invited Review). 

4. Jin,Y.R., Han, X.H., Nishimori, K., Ben-Avraham, D., Oh, Y.J., Shim, J.W., Yoon,J.K. (2020) Canonical WNT/β-Catenin signaling activated by WNT9b and RSPO2 cooperation regulates facial morphogenesis in mice. Frontiers in Cell and Developmental Biology, 8: Article 264.


5. Sah,J.P., Hao, N.T.T., Han, X.H., Tran, T.T.T., McCarthy, S., Oh, Y.J., Yoon,J.K. (2020) Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/β-Catenin signaling. International Journal of Biochemistry and Cell Biology,118: Article 105661.


6. Sah,J.P., Hao, N.T.T., Kim, Y., Eigler, T., Tzahor, E., Kim, S.H., Hwang, Y.S., Yoon,J.K. (2019) MBP-FGF2-immobilized matrix maintains self-renewal and myogenic differentiation potential of skeletal muscle stem cells. International Journal of Stem Cells, 12:360-366.


7. Raslan,A.A., Yoon, J.K. (2019) R-spondins: Multi-mode WNT signaling regulators in adult stem cells. International Journal of Biochemistry and Cell Biology, 106:26-34 (Invited Review).


8. Han,X.H., Jin, Y.R., Tan, L., Kociuk, T., Lee, J.S., Yoon, J.K. (2014) Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-Catenin signaling pathway in skeletal myogenesis. Molecular and Cellular Biology, 34:752-764.


9. Yoon,J.K., Lee, J.S. (2012) Cellular signaling and biological functions of R-spondins. Cellular Signaling 24: 369-377 (Invited Review).


10. Jin,Y.R., Han, X.H., Taketo, M.M., Yoon, J.K. (2012) Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development 139:1821-1830.


11. Chalamalasetty, R.B., Dunty, W.C., Biris, K.K., Ajima,R., Iacovino, M., Beisaw, A., Feigenbaum, L., Chapman, D. L., Yoon, J.K.,Kyba, M., Yamaguchi, T.P. (2011) The Wnt3a/β -catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nature Communications 2:390