순천향의생명연구원(SIMS)

Faculty

Lee, Jongsoon, Ph.D.

Professor, President of SIMS

Insulin Resistance, Type 2 Diabetes, Inflammation, Obesity, Immunity

Room 404, SIMS

+82-41-413-5032

Jongsoon.lee@sch.ac.kr

Lee lab has been studying the underlying molecular mechanisms for the development of obesity-induced insulin resistance, especially focusing on investigating how immune cells are regulated by obesity and how these then mediate the development of obesity-induced systemic insulin resistance. The current research projects of Lee lab are on 1) assessing the metabolic functions of adipose tissue macrophages, 2) determining the role of adipose tissue NK cells in the development of obesity-induced inflammation and insulin resistance, and 3) investigating the molecular mechanisms how adipose tissue inflammation regulates insulin resistance in the liver, muscle and β-cells.

In addition, since insulin resistance and Type 2 Diabetes are systemic diseases, we have hypothesized further that obesity also regulates systemic immune cells and that this controls local inflammation. Lee laboratory has been testing these hypotheses by studying how immune cells in circulation and local tissues are regulated by obesity and how this then mediates the development of obesity-induced insulin resistance in animal models as well as in human, and our accumulating experimental evidence encouragingly supports these hypotheses.

Therefore, we believe that our research not only shows how the fields of metabolism and immunology in insulin resistance and Type 2 Diabetes can interact, it also shows the reciprocal significance of the fields of basic and clinical science.

Principal Investigator

Jongsoon Lee, Ph.D

Professor, Vice-President of SIMS, Director of RLRC

Tel: +82-41-413-5032

Fax: +82-41-413-5006

E-mail: jongsoon.lee@sch.ac.kr

Biography

Education and Training

1979-1983 BS, Department of Zoology, Seoul National University

1983-1985 BS/MS, Department of Zoology, Seoul National University

1988-1994 Ph.D., Department of Biochemistry, Boston University, School of Medicine, Boston, USA

1994-1995 Research Associate, Boston University, School of Medicine, Boston, USA

1995-1999 Research Fellow, Joslin Diabetes Center, Harvard Medical School, Boston, USA

Position

1999-2019 Principal Investigator, Joslin Diabetes Center, Boston, USA

1999-2009 Instructor, Harvard Medical School, Boston, USA

2009-2019 Assistant Professor, Harvard Medical School, Boston, USA

2019-2024 Professor, Soonchunhyang University

2019-2022 Vice President, Soonchunhyang Institute of Medi-Bio Science (SIMS)

2019- Director, Metabolic Disease Tissue Homeostasis Research Center (MHRC/RLRC)

2021-2022 Chair, Department of Integrated Biomedical Science, Soonchunhyang University

2023- President, Soonchunhyang Institute of Medi-Bio Science (SIMS)

2024- Distinguished Research Chair Professor, Soonchunhyang University

Researcher/Lab manager

강하늘 (Haneul Kang)

- E-mail: khaneul.0514@gmail.com

2018-2021 BS, Department of Medical-Bio Technology, SoonChunHyang University

2021-2024 MS Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), SoonChunHyang University, South Korea

2024- Researcher, Soonchunhyang Institute of Medi-bio Science (SIMS), South Korea

Research Topic: The role of circadian rhythm in the development of obesity-induced insulin resistance

Graduate Students

김지은 (Jieun Kim)

- MS/Ph.D. Student

- E-mail: jieun.kim@sch.ac.kr

2015-2019 BS, Department of Medical-Bio Technology, Soon Chun Hyang University

2019- MS/Ph.D. Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea

Research Topic: The role of NK cells in the development of obesity-induced inflammation, insulin resistance and Type 2 Diabetes.

Gracia Nathalie

- MS/Ph.D. Student

- E-mail: gracia.nathalie@sch.ac.kr

2015-2020 BS, Department of Food Technology, Atma Jaya Catholic University, Indonesia

2020.09- MS Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea

Research Topic: The role of classical inflammation in obesity

Eveline

- MS/Ph.D student

- E-mail: evelinee@sch.ac.kr

2018-2022 BS, Department of Biotechnology, Atma Jaya Catholic University, Indonesia

2023- MS/Ph.D student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, South Korea

Research Topic: Exploring the function of adipose tissue LPL in preserving lipid homeostasis amidst obesity-induced insulin resistance

김가희 (Gahui Kim)

- MS/Ph.D student

- E-mail: gahuikim@sch.ac.kr

2020-2024 BS, Department of Biology, SoonChunHyang University

2024- MS/Ph.D student, Department of Integrated Biomedical Science, SoonChunHyang Institute of Medi-Bio Science (SIMS), SoonChunHyang University, South Korea

Research Topic: Research on the heterogeneity and functions of Tissue-resident NK cells and Circulating NK cells

김혜민 (Hyemin Kim)

- MS/Ph.D student

- E-mail: memmin75@sch.ac.kr

2021-2025 BS, Department of Medical-Bio Technology, Soon Chun Hyang University

2025- MS/Ph.D. Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea

Research Topic: The role of E4bp4 in white adipose tissue in obesity-induced type 2 diabetes

Researcher

정지원 (Jiwon Jeong)

- E-mail: jeongjiwon@sch.ac.kr

2013-2017 BS, Department of Biological Science, Hoseo University, South Korea

2017-2019 MS, Department of Biochemistry, Hoseo University, South Korea

2019.05- Researcher, Soonchunhyang Institute of Medi-Bio Science (SIMS), South Korea

Research Topic: The role of adipose tissue macrophages in the development of obesity-induced inflammation and insulin resistance.

이다현 (Dahyeon Lee)

- E-mail: leedahyeon@sch.ac.kr

2016-2021 BS, Department of medical-biotechnology, Dongguk university

2022.09 - Researcher, Soonchunhyang Institute of Medi-bio Science (SIMS), South Korea

Alumini

Emirrio Renaldie Hartland (M.S. 2022)

M.S. thesis title: Transcriptional Regulation of Adipose Tissue by Obesity and Feeding Conditions.

1. Kim, J., Lee, J. (2022) The many faces of the creatine/phosphocreatine system. Nat Metab 4, 155

2. Kim, J., Lee, J. (2021) Role of obesity-induced inflammation in the development of insulin resistance and type 2 diabetes: history of the research and remaining questions. Ann Pediatr Endocrinol Metab 26, 1

3. Kim, Y., Bayona, P.W., Kim, M., Chang, J., Hong, S., Park, Y., Budiman, A., Kim, Y.J., Choi, C.Y., Kim, W.S., Lee,J.$ and Cho,K.W.$(2018) Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance. Front Immunol. 9, 696. $Corresponding author

4. Bonamichi, B. and Lee,J. (2017) Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs. Diabetes Metab J. 41, 229-25

5. Lee, B.C., Kim, M.S., Pae, M., Yamamoto, Y., Eberle, D., Shimada, T., Kamei, N., Park, H.S., Sasorith, S., Woo, J.R., You, J., Mosher, W., Brady, H.J., Shoelson, S.E. and Lee,J. (2016) Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. Cell Metab. 23, 685-69

6. Lee, J.*§, Miyazaki, M.*, Romeo, G.R., Shoelson, S.E.§ (2014) Insulin Receptor Activation with Transmembrane Domain Ligands. J. Biol. Chem. 289: 19769-19777. *Equal contributors. § Corresponding author

7. Lee, B.C. and Lee,J. (2014) Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta. 1842, 446-462

8. Yuan, M.*, Konstantopoulos, N.*, Lee,J.*, Hansen, L., Li, Z.W., Karin, M. and Shoelson, S.E. (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science. 293, 1673-1677. * Equal contributors