TOP

Faculty

  • Hwang, Yongsung, Ph.D.

    Professor, Director of SIMS Research Planning Division

    Biomaterials, Stem cell engineering, ECM remodeling, Mechanotransduction, 3D bioprinting, tumor microenvironment

    Room 205, SIMS

    +82-41-413-5017

    yshwang0428@sch.ac.kr




Developing the next generation of regenerative medicine-based therapies requires a critical understanding encompassing biology, materials science, physiology, medicine, and engineering. Therefore, my research interest lies in:

 

Aim1: Development of novel stem cell-based therapeutics for tissue regeneration We try to (1) develop an efficient strategy to direct lineage-specific in vitro commitment of patient-specific pluripotent stem cells (hPSCs) and mesenchymal stem cells (MSCs) into various musculoskeletal cells, including teno-/osteo-/chondro-/adipo-/myogenic progenitors, and insulin-secreting beta cells by integrating insoluble, matrix-based cues along with soluble cues, and (2) evaluate their tissue regeneration efficacy by biomimetic material-assisted in vivo transplantation and (3) understand cell-cell and cell-matrix interactions using traction force microscopy with FRET biosensors.

 

Aim2: Development and design of cutting-edge biomaterials for recapitulating stem cell niche and disease microenvironments, including degenerative diseases (pteygium, podocyte dysfunction, keloid skin disorder, and osteoarthritis) and various head & neck cancers, in terms of mechanotransduction We try to (1) design and fabricate novel hydrogel-based 3D scaffolds with biomimetic and hierarchical structures for stem cell fate commitment, novel co-culture system, and tumor microenvironment (TME) using 3D printing, 3D melt-electrospinning/spraying, microfabrication techniques and (2) develop functional in vitro disease model platforms as an organ-on-a-chip model and (3) cell surface engineering to modulate cell-cell and cell-matrix interactions for various cellular functions and their subsequent contribution to in vivo tissue repair.

Principal Investigator




Yongsung Hwang, Ph.D.

Biography

B.S. in Materials Science and Engineering, Sungkyunkwan University, Korea

M.S. in Materials Science and Engineering, UC San Diego, USA

Ph.D. in Materials Science and Engineering, UC San Diego, USA

Postdoctoral Researcher, Bioengineering, UC San Diego, USA

Assistant Professor, SIMS, Soonchunhyang University, Korea

Associate Professor, SIMS, Soonchunhyang University, Korea

Professor, SIMS, Soonchunhyang University, Korea

Research Interest

• Development of novel stem cell-based therapeutic for musculoskeletal tissue regeneration including teno-/osteo-/chondro-/adipo-/myogenesis

• Understanding roles of dynamic cell-cell/cell-matrix interactions in lineage specification of human pluripotent stem cells and primary cells isolated from patients using traction force microscopy with FRET biosensors

• Diciphering molecular mechanisms of mechanotransduction-mediated stem cell lineage commitment and tumor microenvironment-associated tumor growth and metastasis

• Investigation of cell surface engineering-induced cell-cell/cell-matrix interactions and their roles in regulating various in vitro cellular functions and in vivo engraftment




Researcher Professor



Sung-Sik Hur, Ph.D.

B.S., Materials Science, Seoul National Univ., Korea, 1995

M.S., Materials Science, Seoul National Univ., Korea, 1998

Ph.D., Bioengineering, UC San Diego, USA, 2007

Postdoctoral Researcher, Bioengineering, UC Irvine, USA, 2007 2008

Postdoctoral Researcher, Bioengineering, UC San Diego, USA, 2009 2013

Assistant Project Scientist, Bioengineering, UC San Diego, USA, 2013-2019

Research Professor, SIMS, Soonchunhyang University, Korea, 2019 current

 

His current research interest is to understand the roles of cell-matrix/cell-cell interactions on controlling the lineage-specific fate determination of human pluripotent stem cells into functional musculoskeletal progenitors and cancer progression and metastasis using Traction Force Microscopy (TFM).




Postdoctoral Researcher


그림입니다.

Joohyun Kim, Ph.D.

B.S., Department of Chemical and Biological Engineering, Gachon Univ., Korea, 2009

M.S., School of Dentistry, Kyungbook National Univ. , Korea, 2012

Ph.D., Gachon Advanced Institute for Health Science and Technology, Korea, 2020

 

Her current research interest is to understand the roles of tumor microenvironment, including multi-celllular components and insoluble extracellular matrix, in controlling the tumor growth and metastasis, focusing on mechanotransduction of head & neck cancer cells.


그림입니다.

원본 그림의 이름: mem00009ae40001.tmp

원본 그림의 크기: 가로 128pixel, 세로 85pixel

George Augustine, Ph.D.

B.S., Plant Biology and Biotechnology, Loyola College, Univ. of Madras, Chennai (India)

M.S., Madurai Kamaraj University, Madurai, India

Ph.D., Anna University, Chennai, India

Senior Research Fellow (SRF), Department of Biochemistry and Biotechnology, CSIR-Central Leather Research Institute, Adyar, Chennai, India




Research Scientist


그림입니다.

원본 그림의 이름: CLP0003e6fc41a0.bmp

원본 그림의 크기: 가로 720pixel, 세로 960pixel

Jinhui Rhee, M.S.

B.S. Life Science, Hoseo University, Republic of Korea

M.S. Biochemistry, Hoseo University, Republic of Korea


그림입니다.

원본 그림의 이름: 반.jpg

원본 그림의 크기: 가로 354pixel, 세로 472pixel

사진 찍은 날짜: 2020년 03월 04일, 오후 5:26

Jiwon Son, M.S.

B.S. Department of Biomedical Science, Cha University, Republic of Korea

M.S. College of Medicine, Korea University, Republic of Korea




Graduate Students


그림입니다.

원본 그림의 이름: CLP00009ae40003.bmp

원본 그림의 크기: 가로 117pixel, 세로 157pixel

Yunhye Kim

B.S., Department of Medical Biotechnology, Soonchunhyang University

Her current Ph.D. research work focuses on understanding the roles of LMNA in chondrocyte de-differentiation and its application.


그림입니다.

원본 그림의 이름: CLP00009ae40004.bmp

원본 그림의 크기: 가로 103pixel, 세로 134pixel

Ji Hoon Jeong

B.S., Department of Medical Biotechnology, Soonchunhyang University

M.S., Department of integrated Biomedical Science, SIMS, Soonchunhyang University

His current Ph.D. research work focuses on fate determination of human pluripotent stem cells through cell-matrix interaction as well as cell surface engineering.


그림입니다.

원본 그림의 이름: CLP00009ae40005.bmp

원본 그림의 크기: 가로 117pixel, 세로 152pixel

Laurensia Danis Anggradita

B.S., Department of Biology, Atma Jaya Catholic Univ., Indoneisa

Her current Ph.D. research work focuses on understanding molecular mechanism of keloid skin disorders and repitulation of 3D keloid skin microenvrionment using skin tissue-derived decellularized extracellular matrix as a 3D printable bioink.