• 송수정, 이학박사


    Cancer metabolism, Bone metastasis, Signaling pathway, Cancer stem cell, Genetic engineered mouse model (GEMM)

    순천향의생명연구원 본관동 406호


암대사(cancer metabolism)와 암의 골전이(Bone metastasis in cancer) 과정의 새로운 조절 기전을 밝히고, 이들을 표적으로 하는 새로운 항암제 개발 및 항암 전략 마련을 위한 기초연구


원본 그림의 이름: picture_SJS.tiff

원본 그림의 크기: 가로 720pixel, 세로 540pixel

1. 대사 조직 기반 암미세환경과 암세포간의 대사 조절 신호전달 연구

2. 새로운 암 발생 및 전이 제어 기전 연구

3. 후성유전학적 조절을 통한 암줄기세포 조절 기전 연구

Principal Investigator

Sujung Song

2008. Ph.D. KAIST

2009. Postdoctoral Training. KAIST

2014. Postdoctoral Training. BIDMC, Harvard Medical School

Present. Associate Professor. SIMS, SCH University

Ph.D Candidate

Rebecca Stephanie Setijono


Research Topic: Identifying a new regulator in cancer initiation and developement

Hyesu Moon


Research Topic: Understanding the role of metabolic reprograming in cancer cells

M.S Candidate

Audrey Christine


Exchange program between SIMS/SCH University and Atma Jaya University

Research Topic: Exploring a new regulatory mechanism of cancer stem cells


Zainab Syeda Ali

Goeun Kim

Siu Sema Langden

1. T Han, S Jiang, H Zheng, Q Yin, M Xie, MR Little, X Yin, M Chen, SJ Song, AA Beg, PP Pandolfi, L Wan. Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. Nat Commun. 2019 Aug;10(1):3716.


2. IK Vila, MK Park, SR Setijono, Y Yao, H Kim, PM Badin, S Choi, V Narkar, SW Choi, J Chung, C Moro, SJ Song*, MS Song*. A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity. JCI Insight. 2019 Jul;4(13).

3. MK Park, Y Yao, W Xia, SR Setijono, JH Kim, IK Vila, H Chiu, Y Wu, E González Billalabeitia, MG Lee, RG Kalb, M Hung, PP Pandolfi, MS Song*, SJ Song*. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nat Commun. 2019. Feb;10(1):636.


4. SR Setijono, MK Park, G Kim, Y Kim, KW Cho, SJ Song. miR-218 and miR-129 Regulate Breast Cancer Progression by Targeting Lamins. Biochem Biophys Res Commun. 2018 Feb;496(3):826833.


5. D Hormaechea-Agulla *, Y Kim*, MS Song , SJ Song. New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O. Mol Cells. 2018 Mar;41(3):168178.


6. SR Setijono, HY Kwon*, SJ Song*. MicroRNA, an antisense RNA, in sensing myeloid malignancies. Front Oncol. 2018 Jan;7:331.


7. IK Vila, SJ Song *, MS Song*. A new duet in cancer biology: AMPK the typical and UBE2O the atypical. Mol Cell Oncol. 2017 Mar;4(3):e1304846.


8. L Wan, M Chen, J Cao, X Dai, Q Yin, J Zhang, SJ Song, Y Lu, J Liu, H Inuzuka, J.M. Katon, K Berry, J Fung, C Ng, P Liu, MS Song, LXue, R. T. Bronson, M.W. Kirschner, R Cui, PP Pandofli, W Wei. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov. 2017 Apr;7(4):424441.


9. IK Vila, Y Yao, G Kim, W Xia, H Kim, SJ Kim, MK Park, JP Hwang, E González-Billalabeitia, MC Hung, SJ Song*, MS Song*. A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017 Feb;31(2):208224.  (Cover Story of February issue on Cancer Cell)


10. CW Choi, J Han, NT Tran, SK Yoon, GE Kim, SJ Song, YJ Kim, SH Ryu. Effective experimental validation of miRNA targets using an improved linker reporter assay. Genetic Res. 2017 Jan;99:e2.


11. YG Yang, IN Sari, MF Zia, SR Lee, SJ Song, HY Kwon, Tetraspanins: Spanning from Solid Tumors to Hematologic Malignancies. Exp Hematol. 2016 May;44(5):322328.


12. SJ Song, PP Pandolfi. MicroRNAs in the pathogenesis of myelodysplastic syndromes and myeloid leukaemia. Curr Opin Hematol. 2014 July;21(4):276282.


13. E González-Billalabeitia, N Seitzer, SJ Song, MS Song, A Patnaik, XS Liu, MT Epping, A Papa, RM Hobbs, M Chen, A Lunardi, C Ng, KA Webster, S Signoretti, M Loda, JM Asara, C Nardella, JG Clohessy, LC Cantley, PP Pandolfi. Vulnerabilities of PTEN-p53-deficient prostate cancers to compound PARP/PI3K inhibition. Cancer Discov. 2014 Aug;4(8):896904.


14. SJ Song, PP Pandolfi. miR-22 in tumorigenesis. Cell Cycle. 2014 Jan;13(1):1112.


15. Y Tay*, SJ Song*, PP Pandolfi. The Lilliputians and the Giant: An emerging oncogenic microRNA network that suppresses the PTEN tumor suppressor in vivo. MicroRNA. 2013 Aug;2:127136.


16. SJ Song, L Poliseno, MS Song, U Ala, K Webster, C Ng, G Beringer, NJ Brikbak, X Yuan, LC Cantley, AL Richardson, PP Pandolfi. MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling. Cell. 2013 Jul;154(2):311324.

17. SJ Song*, K Ito*, U Ala, L Kats, K Webster, SM Sun, M Jongen-Lavrencic, K Manova-Todorova, J Teruya-Feldstein, DE Avigan, R Delwel, PP Pandolfi. The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation. Cell Stem Cell. 2013 Jul;13(1):87101. (Cover Story of July issue on Cell Stem Cell)


18. A Carracedo, D Weiss, AK Leliaert, M Bhasin, VC de Boer, G Laurent, AC Adams, M Sundvall, SJ Song, K Ito, LS Finley, A Egia, T Libermann, Z Gerhart-Hines, P Puigserver, MC Haigis, E Maratos-Flier, AL Richardson, ZT Schafer, PP Pandolfi. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep;122(9):30883100.


19. MS Song, A Carracedo, L Salmena, SJ Song, A Egia, M Malumbres, PP Pandolfi. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell. 2011 Jan;144(2):187199.


20. HJ Oh, MJ Kim, SJ Song, TS Kim, D Lee, SH Kwon, EJ Choi and D-S Lim, Mst1 limits the kinase activity of Aurora B to promote stable kinetochore-microtubule attachment. Curr Biol. 2010 Mar;20(5):416422.


21. SJ Song, SJ Kim, MS Song and D-S Lim, Aurora Bmediated phosphorylation of RASSF1A regulates cytokinesis by recruiting Syntaxin16 onto the midzone and midbody. Cancer Res. 2009 Nov;69(22):85408544.


22. SJ Song, MS Song, SJ Kim, SY Kim, SH Kwon, DF Calvisi, DM Kang and D-S Lim, Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity. Cancer Res. 2009 Mar;69(6):23142323.


23. MS Song*, SJ Song*, SY Kim, HJ Oh and D-S Lim, The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2DAXXHAUSP complex. EMBO J. 2008 Jul;27(13):18631874.


24. MS Song*, SJ Song*, SJ Kim, K Nakayama, K I Nakayama and D-S Lim, Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition. Oncogene. 2008 Mar;27(22):31763185.


25. HJ Oh, KK Lee, SJ Song, JH Lee, CR Im, DS Lim. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res. 2006 Mar;66(5):25622569.


26. MS Song, JS Chang, SJ Song, TH Yang, H Lee, DS Lim. The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles. J Biol Chem. 2005 Feb;280(5):39203927.


27. MS Song, SJ Song, NG Ayad, JS Chang, JH Lee, HK Hong, H Lee, N Choi, J Kim, H Kim, JW Kim, EJ Choi, MW Kirschner, DS Lim. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell. 2004 Feb;6(2):129-37.