연구자
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송수정, 이학박사부교수
Cancer metabolism, Bone metastasis, Signaling pathway, Cancer stem cell, Genetic engineered mouse model (GEMM)
순천향의생명연구원 본관동 406호
041-413-5030
ssong1@sch.ac.kr
암대사(cancer metabolism)와 암의 골전이(Bone metastasis in cancer) 과정의 새로운 조절 기전을 밝히고, 이들을 표적으로 하는 새로운 항암제 개발 및 항암 전략 마련을 위한 기초연구
1. 대사 조직 기반 암미세환경과 암세포간의 대사 조절 신호전달 연구
2. 새로운 암 발생 및 전이 제어 기전 연구
3. 후성유전학적 조절을 통한 암줄기세포 조절 기전 연구
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Principal Investigator Sujung Song 2008. Ph.D. KAIST 2009. Postdoctoral Training. KAIST 2014. Postdoctoral Training. BIDMC, Harvard Medical School Present. Associate Professor. SIMS, SCH University Ph.D Candidate Rebecca Stephanie Setijono E-mail: rebeccasteph06@sch.ac.kr Research Topic: Identifying a new regulator in cancer initiation and developement Hyesu Moon E-mail: hyesumoon0203@sch.ac.kr Research Topic: Understanding the role of metabolic reprograming in cancer cells M.S Candidate Audrey Christine E-mail: 20207192@sch.ac.kr Exchange program between SIMS/SCH University and Atma Jaya University Research Topic: Exploring a new regulatory mechanism of cancer stem cells Alumni Zainab Syeda Ali Goeun Kim Siu Sema Langden |
1. T Han, S Jiang, H Zheng, Q Yin, M Xie, MR Little, X Yin, M Chen, SJ Song, AA Beg, PP Pandolfi, L Wan. Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. Nat Commun. 2019 Aug;10(1):3716.
2. IK Vila, MK Park, SR Setijono, Y Yao, H Kim, PM Badin, S Choi, V Narkar, SW Choi, J Chung, C Moro, SJ Song*, MS Song*. A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity. JCI Insight. 2019 Jul;4(13).
3. MK Park, Y Yao, W Xia, SR Setijono, JH Kim, IK Vila, H Chiu, Y Wu, E González Billalabeitia, MG Lee, RG Kalb, M Hung, PP Pandolfi, MS Song*, SJ Song*. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nat Commun. 2019. Feb;10(1):636.
4. SR Setijono, MK Park, G Kim, Y Kim, KW Cho, SJ Song. miR-218 and miR-129 Regulate Breast Cancer Progression by Targeting Lamins. Biochem Biophys Res Commun. 2018 Feb;496(3):826–833.
5. D Hormaechea-Agulla *, Y Kim*, MS Song , SJ Song. New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O. Mol Cells. 2018 Mar;41(3):168–178.
6. SR Setijono, HY Kwon*, SJ Song*. MicroRNA, an antisense RNA, in sensing myeloid malignancies. Front Oncol. 2018 Jan;7:331.
7. IK Vila, SJ Song *, MS Song*. A new duet in cancer biology: AMPK the typical and UBE2O the atypical. Mol Cell Oncol. 2017 Mar;4(3):e1304846.
8. L Wan, M Chen, J Cao, X Dai, Q Yin, J Zhang, SJ Song, Y Lu, J Liu, H Inuzuka, J.M. Katon, K Berry, J Fung, C Ng, P Liu, MS Song, LXue, R. T. Bronson, M.W. Kirschner, R Cui, PP Pandofli, W Wei. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov. 2017 Apr;7(4):424–441.
9. IK Vila, Y Yao, G Kim, W Xia, H Kim, SJ Kim, MK Park, JP Hwang, E González-Billalabeitia, MC Hung, SJ Song*, MS Song*. A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017 Feb;31(2):208–224. (Cover Story of February issue on Cancer Cell)
10. CW Choi, J Han, NT Tran, SK Yoon, GE Kim, SJ Song, YJ Kim, SH Ryu. Effective experimental validation of miRNA targets using an improved linker reporter assay. Genetic Res. 2017 Jan;99:e2.
11. YG Yang, IN Sari, MF Zia, SR Lee, SJ Song, HY Kwon, Tetraspanins: Spanning from Solid Tumors to Hematologic Malignancies. Exp Hematol. 2016 May;44(5):322–328.
12. SJ Song, PP Pandolfi. MicroRNAs in the pathogenesis of myelodysplastic syndromes and myeloid leukaemia. Curr Opin Hematol. 2014 July;21(4):276–282.
13. E González-Billalabeitia, N Seitzer, SJ Song, MS Song, A Patnaik, XS Liu, MT Epping, A Papa, RM Hobbs, M Chen, A Lunardi, C Ng, KA Webster, S Signoretti, M Loda, JM Asara, C Nardella, JG Clohessy, LC Cantley, PP Pandolfi. Vulnerabilities of PTEN-p53-deficient prostate cancers to compound PARP/PI3K inhibition. Cancer Discov. 2014 Aug;4(8):896–904.
14. SJ Song, PP Pandolfi. miR-22 in tumorigenesis. Cell Cycle. 2014 Jan;13(1):11–12.
15. Y Tay*, SJ Song*, PP Pandolfi. The Lilliputians and the Giant: An emerging oncogenic microRNA network that suppresses the PTEN tumor suppressor in vivo. MicroRNA. 2013 Aug;2:127–136.
16. SJ Song, L Poliseno, MS Song, U Ala, K Webster, C Ng, G Beringer, NJ Brikbak, X Yuan, LC Cantley, AL Richardson, PP Pandolfi. MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling. Cell. 2013 Jul;154(2):311–324.
17. SJ Song*, K Ito*, U Ala, L Kats, K Webster, SM Sun, M Jongen-Lavrencic, K Manova-Todorova, J Teruya-Feldstein, DE Avigan, R Delwel, PP Pandolfi. The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation. Cell Stem Cell. 2013 Jul;13(1):87–101. (Cover Story of July issue on Cell Stem Cell)
18. A Carracedo, D Weiss, AK Leliaert, M Bhasin, VC de Boer, G Laurent, AC Adams, M Sundvall, SJ Song, K Ito, LS Finley, A Egia, T Libermann, Z Gerhart-Hines, P Puigserver, MC Haigis, E Maratos-Flier, AL Richardson, ZT Schafer, PP Pandolfi. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep;122(9):3088–3100.
19. MS Song, A Carracedo, L Salmena, SJ Song, A Egia, M Malumbres, PP Pandolfi. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell. 2011 Jan;144(2):187–199.
20. HJ Oh, MJ Kim, SJ Song, TS Kim, D Lee, SH Kwon, EJ Choi and D-S Lim, Mst1 limits the kinase activity of Aurora B to promote stable kinetochore-microtubule attachment. Curr Biol. 2010 Mar;20(5):416–422.
21. SJ Song, SJ Kim, MS Song and D-S Lim, Aurora B–mediated phosphorylation of RASSF1A regulates cytokinesis by recruiting Syntaxin16 onto the midzone and midbody. Cancer Res. 2009 Nov;69(22):8540–8544.
22. SJ Song, MS Song, SJ Kim, SY Kim, SH Kwon, DF Calvisi, DM Kang and D-S Lim, Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity. Cancer Res. 2009 Mar;69(6):2314–2323.
23. MS Song*, SJ Song*, SY Kim, HJ Oh and D-S Lim, The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2–DAXX–HAUSP complex. EMBO J. 2008 Jul;27(13):1863–1874.
24. MS Song*, SJ Song*, SJ Kim, K Nakayama, K I Nakayama and D-S Lim, Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition. Oncogene. 2008 Mar;27(22):3176–3185.
25. HJ Oh, KK Lee, SJ Song, JH Lee, CR Im, DS Lim. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res. 2006 Mar;66(5):2562–2569.
26. MS Song, JS Chang, SJ Song, TH Yang, H Lee, DS Lim. The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles. J Biol Chem. 2005 Feb;280(5):3920–3927.
27. MS Song, SJ Song, NG Ayad, JS Chang, JH Lee, HK Hong, H Lee, N Choi, J Kim, H Kim, JW Kim, EJ Choi, MW Kirschner, DS Lim. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell. 2004 Feb;6(2):129-37.
