연구자
-
이종순, 이학박사교수, 원장
Insulin Resistance, Type 2 Diabetes, Inflammation, Obesity, Immunity
순천향의생명연구원 본관동 404호
041-413-5032
Jongsoon.lee@sch.ac.kr
전세계적으로, 비만 환자는 계속해서 증가하고 있으며, 당뇨병 환자들의 유병률 또한 급속히 증가하고 있다. 기존의 연구로 비만이 당뇨병을 유발하는데 있어서 가장 중요한 원인이라는 것은 확립되어 있지만, 비만이 어떠한 기작을 통해 제 2형 당뇨병을 유발하는가에 대한 것은 완전히 알려져 있지 않다. 최근의 연구들은 비만으로 의한 염증반응이 당뇨 전단계인 인슐린 저항성을 유발하는데 중요한 역할을 하며, 특히 내장지방에서 면역세포들이 이 과정을 조절한다는 것을 보여주고 있다.
본 연구실은 어떻게 면역세포들이 비만에 의해 조절되고, 그 후 이러한 면역세포에 의하여 유도된 염증반응이 어떻게인슐린 저항성을 유발하는 가를 연구함으로써, 비만에 의한 인슐린 저항성 발달에 대한 분자적 기전을 연구를 진행하고 있다. 특히 본 연구실은 1) Adipose tissue macrophage (ATMs)의 대사적 기능 평가, 2) 비만-유도 염증과 전신적 인슐린 저항성에서 지방조직 NK cells의 역할 규명, 3) 지방 조직의 염증반응이 간, 근육, b-cells에서의 인슐린 저항성을 조절하는 분자적 기전에 대한 연구들을 진행하고 있다.
또한 인슐린 저항성과 제 2형 당뇨병은 전신적 질병이기 때문에, 우리는 비만이 전신적 면역 세포들을 먼저 활성화 시키고, 이들이 인슐린 저항성의 발달을 유발시키는 지방조직의 국소적 염증을 유도할 것이라고도 가정하고 있다. 따라서, 본 연구실은 순환성과 국소 조직에 있는 면역 세포들이 어떻게 비만에 의해 조절되며, 이후 어떻게 이 세포들이 유도 인슐린 저항성의 발달을 조절하는지에 대한 연구를 진행함으로써 이 가설을 검증하고 있다
따라서, 우리는 본 연구실의 이러한 대사 질환 연구와 면역 질환 연구라는 융합 연구를 통하여, 제 2형 당뇨병 치료를 위한 새로운 치료법을 개발하고자 한다.
|
Principal Investigator
Jongsoon Lee, Ph.D Professor, Vice-President of SIMS, Director of RLRC Tel: +82-41-413-5032 Fax: +82-41-413-5006 E-mail: jongsoon.lee@sch.ac.kr Biography Education and Training 1979-1983 BS, Department of Zoology, Seoul National University 1983-1985 BS/MS, Department of Zoology, Seoul National University 1988-1994 Ph.D., Department of Biochemistry, Boston University, School of Medicine, Boston, USA 1994-1995 Research Associate, Boston University, School of Medicine, Boston, USA 1995-1999 Research Fellow, Joslin Diabetes Center, Harvard Medical School, Boston, USA Position 1999-2019 Principal Investigator, Joslin Diabetes Center, Boston, USA 1999-2009 Instructor, Harvard Medical School, Boston, USA 2009-2019 Assistant Professor, Harvard Medical School, Boston, USA 2019-2024 Professor, Soonchunhyang University 2019-2022 Vice President, Soonchunhyang Institute of Medi-Bio Science (SIMS) 2019- Director, Metabolic Disease Tissue Homeostasis Research Center (MHRC/RLRC) 2021-2022 Chair, Department of Integrated Biomedical Science, Soonchunhyang University 2023- President, Soonchunhyang Institute of Medi-Bio Science (SIMS) 2024- Distinguished Research Chair Professor, Soonchunhyang University Researcher/Lab manager
강하늘 (Haneul Kang) - E-mail: khaneul.0514@gmail.com 2018-2021 BS, Department of Medical-Bio Technology, SoonChunHyang University 2021-2024 MS Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), SoonChunHyang University, South Korea 2024- Researcher, Soonchunhyang Institute of Medi-bio Science (SIMS), South Korea Research Topic: The role of circadian rhythm in the development of obesity-induced insulin resistance Graduate Students
김지은 (Jieun Kim) - MS/Ph.D. Student - E-mail: jieun.kim@sch.ac.kr 2015-2019 BS, Department of Medical-Bio Technology, Soon Chun Hyang University 2019- MS/Ph.D. Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea Research Topic: The role of NK cells in the development of obesity-induced inflammation, insulin resistance and Type 2 Diabetes.
Gracia Nathalie - MS/Ph.D. Student - E-mail: gracia.nathalie@sch.ac.kr 2015-2020 BS, Department of Food Technology, Atma Jaya Catholic University, Indonesia 2020.09- MS Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea Research Topic: The role of classical inflammation in obesity
Eveline - MS/Ph.D student - E-mail: evelinee@sch.ac.kr 2018-2022 BS, Department of Biotechnology, Atma Jaya Catholic University, Indonesia 2023- MS/Ph.D student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, South Korea Research Topic: Exploring the function of adipose tissue LPL in preserving lipid homeostasis amidst obesity-induced insulin resistance
김가희 (Gahui Kim) - MS/Ph.D student - E-mail: gahuikim@sch.ac.kr 2020-2024 BS, Department of Biology, SoonChunHyang University 2024- MS/Ph.D student, Department of Integrated Biomedical Science, SoonChunHyang Institute of Medi-Bio Science (SIMS), SoonChunHyang University, South Korea Research Topic: Research on the heterogeneity and functions of Tissue-resident NK cells and Circulating NK cells
김혜민 (Hyemin Kim) - MS/Ph.D student - E-mail: memmin75@sch.ac.kr 2021-2025 BS, Department of Medical-Bio Technology, Soon Chun Hyang University 2025- MS/Ph.D. Student, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, South Korea Research Topic: The role of E4bp4 in white adipose tissue in obesity-induced type 2 diabetes Researcher
정지원 (Jiwon Jeong) - E-mail: jeongjiwon@sch.ac.kr 2013-2017 BS, Department of Biological Science, Hoseo University, South Korea 2017-2019 MS, Department of Biochemistry, Hoseo University, South Korea 2019.05- Researcher, Soonchunhyang Institute of Medi-Bio Science (SIMS), South Korea Research Topic: The role of adipose tissue macrophages in the development of obesity-induced inflammation and insulin resistance.
이다현 (Dahyeon Lee) - E-mail: leedahyeon@sch.ac.kr 2016-2021 BS, Department of medical-biotechnology, Dongguk university 2022.09 - Researcher, Soonchunhyang Institute of Medi-bio Science (SIMS), South Korea Alumini
Emirrio Renaldie Hartland (M.S. 2022) M.S. thesis title: Transcriptional Regulation of Adipose Tissue by Obesity and Feeding Conditions. |
1. Kim, J., Lee, J. (2022) The many faces of the creatine/phosphocreatine system. Nat Metab 4, 155
6. Lee, J.*§, Miyazaki, M.*, Romeo, G.R., Shoelson, S.E.§ (2014) Insulin Receptor Activation with Transmembrane Domain Ligands. J. Biol. Chem. 289: 19769-19777. *Equal contributors. § Corresponding author
8. Yuan, M.*, Konstantopoulos, N.*, Lee,J.*, Hansen, L., Li, Z.W., Karin, M. and Shoelson, S.E. (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science. 293, 1673-1677. * Equal contributors
