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Seminars

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[Seminar Notification] : Jee Hee Youn, Ph.D. (03.14.2019)
2019-03-08


1. Title:Regulation of autoantibody production in lupus models
2. Speaker: Jeehee Youn, Ph.D.
3. Affiliation:Department of Anatomy and Cell Biology,Department of Biomedical Science, Hanyang University
4. Date: 2019. 03.14. (Thu) 16:00
5. Place: SIMS Main Building, Auditorium 109(1F)
6. Abstract:

Systemic lupus erythematosus (SLE or lupus) is a chronic inflammatory autoimmune disease,

characterized by production of anti-nuclear antibodies (ANA) as a result of a loss of tolerance

to nuclear antigens. The occurrence of IgG class switch recombination (CSR) during plasma

cell differentiation seems to be crucial for the SLE pathology, since IgG ANA deposit in

tissues as immune complexes, leading to inflammation and end organ damage in the kidneys,

skin, and more, whereas IgM ANA are protective against autoimmunity. Although the CSR

has been traditionally regarded to occur exclusively during germinal center responses, recent

insights have implicated the extrafollicular pathway in the production of pathogenic

autoantibodies for SLE. Autoreactive B cells may preferentially diversify into extrafollicular

plasma cells rather than germinal center B cells upon activation, due to follicular exclusion

and germinal center checkpoints of self-reactivity. In this context, clarifying the mechanics

and genetic risk alleles for the extrafollicular response is critical for understanding the

pathogenesis of autoantibody-mediated diseases. Here, we propose a transcription repressor

Bach2 as a genetic factor regulating the susceptibility to SLE. We will discuss how the

absence of Bach2 activates the extrafollicular pathway to produce IgG-switched

autoantibodies.